Stem Cell Research-Incredible Results

-U.S. Coalition Opposes Stem Cell Research

-Boy Cured Of Sickle Cell With Stem Cell Transplants

-Stem Cell Transplant in Mice Hailed- Developed into Sperm Cells

U.S. Coalition Opposes Stem Cell Research

Updated 12:50 AM ET July 2, 1999By Maggie Fox, Health and Science Correspondent
WASHINGTON (Reuters)


- A coalition of religious experts, doctors, scientists and politicians spoke out against stem cell research Thursday, saying it was unethical and scientifically questionable.

They called on Congress to maintain legislation outlawing the use of human embryos -- which other scientists say may be the best source of stem cells, the so-called nursery or master cells that give rise to other types of cells in the body.

"We believe that research being proposed by the National Institutes of Health (NIH) on human embryonic stem cells is immoral, illegal and unnecessary," Kansas Republican Sen. Sam Brownback told a news conference.

Research in the past year has found that stem cells might be used to treat Parkinson's, juvenile diabetes and other diseases and could provide tissue for transplants and tests. The cells come from embryos and tissues of the body and blood.

The embryonic stem cells are "pluripotent" -- they can develop into any kind of cell in the body. Embryos used are from miscarriages or abortions, or are left over from attempts at making test-tube babies.
At least one company, California-based Geron Corp, proposes cloning human embryos as sources of stem cells.

The National Bioethics Advisory Commission says this research holds so much promise that Congress should lift part of its ban on using federal money for research on embryonic stem cells.
But the opposing coalition called the idea distasteful and disturbing.

"The work begins with the destruction of a living being," Dr. Frank Young, a former commissioner of the U.S. Food and Drug Administration and an ordained evangelical minister, told the news conference.
"Moreover, destruction of human embryonic life is unnecessary for medical progress, as alternative methods of obtaining human stem cells and of repairing and regenerating human tissue exist and continue to be developed," the group, sponsored by the Center for Bioethics and Human Dignity in Bannockburn, Illinois, said in a statement.

Signatories included former surgeon-general Dr. C. Everett Koop, Samuel Casey, executive director of the Christian Legal Society, and Richard Doerflinger of the National Conference of Catholic Bishops.
U.S. law bans the use of public funds to pay for research that damages or manipulates live human embryos, and prohibits the use of federal funds to create human embryos solely for research. Most recent work showing the potential of stem cells has been funded by private firms.

A new lobbying group, the Patients' Coalition for Urgent Research (CURE), in May released a survey of 1,000 adults that showed 74 percent supported human stem cell research, even when the cells came from embryos. But groups like Brownback's say there are better sources for stem cells than embryos, and cite research showing the cells can be taken from blood, the brain and other sources.

In May scientists at the University of Pittsburgh said bone marrow cells transplanted into rats migrated to their livers and helped repair them, and in March a group at the Howard Hughes Medical Institute in Pasadena, California, said it had found and grown stem cells from living nerve tissue.

Other researchers, like John Gearhart of Johns Hopkins University in Baltimore, say scientists have to investigate all sources of stem cells. They note that embryonic stem cells automatically have the ability to become any type of cell in the body, while other types, such as blood stem cells, have restricted functions and must be manipulated to create muscle or nerve tissue.

"At this stage all avenues of scientific inquiry must remain open," Patient's CURE said in a statement Thursday. "Only embryonic stem cells, with their capacity to become any kind of human tissue, have the potential to repair all vital organs."

 

 Boy Cured Of Sickle Cell Anemia

updated 9:06 Pm Et December 13, 1999atlanta (Ap) -

A 13-Year-old Boy Who Underwent An Experimental Blood Cell Transfusion Was Declared Cured Of Sickle Cell Anemia Monday.

Doctors Had Replaced The Bone Marrow Of Keone Penn With Stem Cells From The Umbilical Cord Of An Unrelated Infant In The Hopes That The New Cells Would Produce Healthy Marrow, Which In Turn Produces Blood Cells.

"I'm Talking, My Heart Is Beating And My Brain Is Working," Keone Said In A Statement From Children's Healthcare Of Atlanta. "I Made It." The Transplant Was Performed Dec. 11, 1998, And Was Believed To Be The First Time Unrelated Cord Blood Has Been Used To Treat Sickle Cell Anemia - An Inherited, Crippling And Sometimes Lethal Disease Prevalent Among Blacks.

Doctors Had Said That They Would Wait A Year To See If The Stem Cells Were Creating Healthy Blood Before Declaring Keone Cured.

"The Cord Blood Cells Are Now Fully Operational, Making All Healthy Blood Cells. ... We See No Signs Of Sickle Cells," Said Dr. Andrew M. Yeager, The Emory University Physician Who Performed The Procedure.

The Procedure Could Mean An Alternative To Painful Bone Marrow Transplants As A Way Of Treating Sickle Cell, Which Is Caused By Defective Bone Marrow That Creates Irregularly Shaped Cells That Are Unable To Pass Through Tiny Blood Vessels.

Before Keone Received The Stem Cells, Doctors Had Given The Procedure A 50-50 Chance Of Working.

 

Stem Cell Transplant in Mice Hailed

Tuesday December 28 2:39 AM ETBy RANDOLPH E. SCHMID Associated Press Writer
WASHINGTON (AP) -

Young men left infertile by cancer treatments might still have a chance to be fathers if a successful sperm transplant experiment in mice can be applied to humans.

Scientists transplanted the stem cells from one type of mouse into another. The cells then developed into sperm cells, carrying the traits of the donor male. The work was done by a team of researchers led by Ralph L. Brinster of the University of Pennsylvania School of Veterinary Medicine. While the work was done only in mice, it could have major implications for some young human cancer patients, Howard J. Cooke of Western General Hospital in Edinburgh, Scotland, reports in an accompanying news article.


Because some cancer treatments can cause mutations in developing and mature sperm cells, men undergoing these treatments often have sperm removed and frozen for later use. This cannot be done for boys who have not yet gone through puberty since they have no mature sperm cells.

Cooke and colleague Philippa K. T. Saunders say Brinster's work indicates that if immature stem cells can develop successfully after transplantation, they can be frozen and reintroduced into the donor after completion of cancer treatment. Frozen preservation ``of testicular stem cells and post-treatment reintroduction, could protect germ cells from potentially (mutation-causing) cancer treatments and safeguard against infertility,'' Cooke and Saunders concluded.

However, they caution, doctors must not reintroduce cancer cells into the patient in this process.
They also noted that the ability to separate, preserve and reintroduce stem cells raises the possibility of using gene therapy to correct genetic problems. But they added: ``Ethical problems with this approach abound.''

The findings, developed in a study of whether fertility can be restored in infertile males, are reported in today's issue of the journal Nature Medicine. ``It certainly looks very promising, in particular the fact that they were able to get the new sperm-generating cells into testes that didn't have these sperm generating cells in them for most of their lives,'' said Evelio Perez-Albuerne, an attending physician in the Hematology-Oncology Department at the Children's National Medical Center in Washington, who was not involved in the research..

``This is also exciting,'' he added, ``because this was one of the first times people have actually talked about there being offspring, as opposed to just being sperm cells under a microscope.''

 

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